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Lee J, Lee G, Park JH, Lee S, Yeom C-H, Na B, et al

TNF-a and IL-6 have, in separate studies, both been identified as potentially key immune factors in ME/CFS The authors go on to note that, in some cases, mental fatigue persists long after the identified neural trauma has been resolved (perhaps due to a genetic predisposition or due to dendritic remodelling) and emphasise the importance of early treatment to prevent the problem becoming chronic : Providing information about mental fatigue, its cause and the prognosis, is of utmost importance for breaking the vicious circle, which comes with the risk for secondary anxiety and depression

Noom, Calibrate, and Embla say there is preliminary data to support their contention that many people can maintain weight loss through exercise and diet after stopping the medications (though some of the doctors Fortune spoke with were skeptical of those studies)